Hypoxia inducible factor (HIF) 1α/2α, glucocorticoid receptor (GR), and the phosphorylated S134-GR/PELP1/HIF signaling complex have been shown to induce the expression of PTK6, thus promoting the survival and metastasis of tumor cells [29, 44, 45]. This evidence concerns the gene NR3C1 and neoplasm.