GADD45GIP1 and atrial fibrillation: In order to explore the potential mechanisms through which high-fat conditions contribute to the progression of AF, the present study hypothesizes that high-fat stimulation induces atrial fibrillation (AF) by disrupting the balance of nitric oxide (NO) and promoting atrial nerve remodeling through the CRIF1/eNOS/P21 axis via mitochondrial damage.