Consistent with the levels that are measured patients with neurodegenerative diseases like Alzheimer’s disease (it includes both prodromal AD and dementia due to AD), Parkinson’s disease, and Parkinson’s disease dementia, our study found that the mean fold increase of NfL in the young migraineurs group with  10 year of migraine history was less than 2. Here, NEFL is linked to neurodegenerative disease.