Yu et al. demonstrated that TNFα enhanced the protein expression of Twist by activating the NF-κB signalling pathway and induced EMT and metastasis in nasopharyngeal carcinoma cells, while inhibiting NF-κB expression with siRNA-65 or Bay11-7082 decreased the protein expression of Twist and inhibited tumour metastasis [21]. Here, TWIST1 is linked to neoplasm.