HS6ST2 was highly expressed in bladder urothelial carcinoma (BLCA), cholangiocarcinoma (CHOL), pheochromocytoma and paraganglioma (PCPG), colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), LUAD, thyroid carcinoma (THCA), and lung squamous cell carcinoma (LUSC). This evidence concerns the gene HS6ST2 and bladder transitional cell carcinoma.