HS6ST2 expression was negatively correlated with NSUN4 and YTHDF2 in LUSC, testicular germ cell tumors (TGCT), and brain lower grade glioma (LGG) but positively correlated with NSUN4 and YTHDF2 in BLCA, cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), HNSC, KICH, uveal melanoma (UVM), LUAD, and PRAD (Fig. 2A). The gene discussed is HS6ST2; the disease is prostate adenocarcinoma.