Cox regression analysis revealed that low HS6ST2 expression was connected with poorer OS in breast invasive carcinoma, mesothelioma, kidney renal clear cell carcinoma, uveal melanoma, and adrenocortical carcinoma but associated with better OS in rectum adenocarcinoma and bladder urothelial carcinoma (Fig. 3A). The gene discussed is HS6ST2; the disease is rectum adenocarcinoma.