Consistent with the reported tumor-promoting role of SMC1A30 and elevated expression of SMC1A in COAD tumor tissues compared with normal colon tissues (Fig. 6a), we confirmed that siRNA-mediated silencing of SMC1A (Fig. 6b) suppressed CRC cell growth and colony formation (Fig. 6c–f). Here, SMC1A is linked to colon adenocarcinoma.