GC and neoplasm: Previous studies have demonstrated that MARCH5 inhibits mitochondrial fission by promoting Drp1 degradation,36,60 whereas other studies suggest that MARCH5 is required for Drp1-dependent mitochondrial division.58,61 In addition, it has also been reported that MARCH5 is partially localized at the peroxisome to regulate pexophagy.37 Whether and how the functions of MARCH5 in these cellular processes other than its down-regulation of γc are involved in its regulation of anti-tumor immunity needs to be investigated in future studies.