In addition, the level of γc was not markedly changed in SHP2-deficient HPB-ALL or Jurkat-PD-1 cells comparing to their wild-type counterparts (Fig. 5e, f), suggesting that JAK3-mediated phosphorylation and SHP2-mediated dephosphorylation of γc is not involved in MARCH5-mediated down-regulation of γc. The gene discussed is JAK3; the disease is acute lymphoblastic leukemia.