The level of JAK3 was not markedly changed in SHP2-deficient HPB-ALL cells comparing to their wild-type counterparts (Supplementary information, Fig. S5b), There are 4 tyrosine residues in the intracellular region (284–369 aa) of γc (Supplementary information, Fig. S5c). Here, PTPN11 is linked to acute lymphoblastic leukemia.