GC and acute lymphoblastic leukemia: Pitavastatin has also been reported to have pleiotropic beneficial effects such as suppression of inflammation, regulation of angiogenesis and osteogenesis, improvement of endothelial function and arterial stiffness.43 Recent studies have also shown that PC has anti-tumor activity by promoting tumor cell apoptosis.44,45 Consistent with a specific inhibition of MARCH5 activity in the reporter system, PC treatment up-regulated the level of γc in a dose-dependent manner in all examined cells including primary human and mouse CD8+ T cells, and Jurkat, HPB-ALL and CTLL2 cells (Fig. 7a).