Further, BRCA2/ATM carrier status was an independent predictor of OS from mCRPC diagnosis (HR 4.12, 95% C: 1.85–9.19, P = 0.0005, Fig. 2d), in agreement with results from Na et al.10, who reported BRCA1/2 and ATM carrier status to be a significant predictor of poor cause-specific survival in a cohort of localized and metastatic PC patients. This evidence concerns the gene ATM and pachyonychia congenita.