In conclusion, it was suggested that hypoferremia due to the effect of hepcidin decreases iron in the environment of extracellular pathogens, the increase in LCN2 levels directly inhibits siderophores during the acute phase of infection, and these effects of hepcidin and LCN2 associated with the inflammatory response prevents iron acquisition by the pathogen in each manner. This evidence concerns the gene HAMP and infection.