KEGG pathway analysis revealed that the top6 KEGG pathways enriched by key module genes include ‘TNF signaling pathway’, ‘IL-17 signaling pathway’, ‘Rheumatoid arthritis’, ‘Viral protein interaction with cytokine and cytokine receptor’, ‘NOD-like receptor signaling pathway’ and ‘NF-kappa B signaling pathway’ (Fig. 10A). The gene discussed is TNF; the disease is rheumatoid arthritis.