Specifically, previous studies have demonstrated NETs were found to be enriched in the peripheral blood and synovial fluid of RA patients, in which the NETs overexpression significantly enhances the inflammatory reaction of RA synovial fibroblasts by inducing the production of IL-6, IL-8, chemokines, and adhesion molecules that leads to substantial joint damages40, 41. The gene discussed is CXCL8; the disease is rheumatoid arthritis.