Immune response-related genes that were downregulated in the tumor tissues of patients with PDTC compared to normal thyroid tissues included TAP1, AIM2, and MICB. TAP1 downregulation is associated with immune evasion and unfavorable prognosis in rectal cancer38, and AIM2 is a known tumor suppressor gene in melanoma39. The gene discussed is AIM2; the disease is neoplasm.