GSDMD and colonic neoplasm: For example, Liu et al. showed that the selenoprotein receptor thioredoxin Reductase 3 (Txnrd3) expressed in the mouse colon and led to increased ER stress and Ca2+ release, which subsequently fostered the expression of NLRP3 and Gasdermin D (GSDMD) that could promote pyroptosis, thereby blunting the growth and proliferation of colon cancer cells [87].