MCU promotes cystine/glutamate antiporter SLC7A11 expression through activation of the Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) antioxidant pathway, which in turn promotes the migration, invasion and metabolic stress resistance in pancreatic ductal adenocarcinoma (PDAC) cells [91]. Here, NFE2L2 is linked to pancreatic ductal adenocarcinoma.