Interestingly, we found several of these genes (ATP8B3, FOXR2, FRG2, HIST1H4A) to act as cancer stemness regulators, able to regulate cancer stem cell self-renewal activity and expression of the endothelial protein C receptor (EPCR), a specific stemness marker for TNBC [20, 21]. The gene discussed is ATP8B3; the disease is cancer.