The results indicate that the risk allele NC_000005.10:g.132457732dup renders severity of COVID-19 through upregulating RAD50, and NC_000001.11:g.77984833C>A, NC_000005.10:g.132448315C>T, and NC_000008.11:g.60515641C>T contribute to the hospitalization of COVID-19 through downregulating FUBP1 and upregulating RAD50 and RAB2A, respectively. The gene discussed is RAD50; the disease is COVID-19.