FNIP1 and ischemia: To determine the role of FNIP1 in ischemic revascularization, we applied unilateral hindlimb ischemia to both FNIP1 MKO and Fnip1f/f littermate mice, and we assessed macrophage recruitment and neoangiogenesis after the induction of hindlimb ischemia in both the contralateral and ischemic muscles (Fig. 7a–f).