To identify patients with pre-malignant expansions with 11p15.5 alteration, we screened non-tumor tissues from 115 patients (110 livers, 9 blood, 1 lung samples) with PLC for chromosome 11p15.5 copy-number alterations and IC1/IC2 methylation status using WES, WGS, and MS-MLPA (Fig. 1, Supplementary Fig. 3–5, Supplementary Data 1). The gene discussed is HSPG2; the disease is neoplasm.