Based on the expression of CD16 and CD10 (established markers for neutrophil maturity) (Marini et al, 2017), these two LDN subpopulations are analogous to the immature and mature neutrophil populations previously observed in the blood of head-and-neck cancer and melanoma patients (Lang et al, 2018; Gondois-Rey et al, 2021). Here, MME is linked to head and neck cancer.