Further studies have confirmed that macrophage-derived chemokines (including CCL24) and cytokines (including IL-2 and IL-12) promote the recruitment and activation of T cells, eosinophils, neutrophils and the corresponding immune responses, in addition to increasing the cytotoxicity of NK cells in the defense against parasitic [53, 54] or viral infections [55–59]. This evidence concerns the gene IL2 and viral infectious disease.