COL3A1 and Hepatic fibrosis: In addition, hepatic macrophage depletion apparently attenuated liver fibrosis, as evaluated by SR and Col3α1 staining, at 1, 2 and 24 weeks (SR staining: P = 0.0057 at 1 week; P < 0.0001 at 2 weeks; P = 0.0111 at 24 weeks; Col3α1 staining: P = 0.1000 at 1 week; P = 0.0317 at 2 weeks; P = 0.0571 at 24 weeks) (Figs 5C, 5F and S4).