Notably, an attenuated OR for APOE*44 with AD risk was observed with high Amerindian ancestry, which appears in line with a previously reported lack of APOE*4 associations with neurodegeneration among American Indian individuals.26 Furthermore, our findings indicated that differences in ORs for APOE*4 and AD risk were more pronounced when comparing African with European ancestry than when comparing Black with White individuals. Here, APOE is linked to Alzheimer disease.