APOE and Alzheimer disease: Despite the novel 2023 National Academies of Sciences, Engineering, and Medicine guidelines on using population descriptors in genetics,28 it is relevant to note that we focused on the current racial and ethnic groups given their widespread use in AD (including genomics, clinical trials, and broad AD research) and previously established effects on stratifying APOE-related risk for AD.3 The choice was additionally motivated given that more granular information regarding population or environmental variables was not readily available across the various included cohorts.