While among East Asian and Hispanic individuals there was no significant association of APOE*22 and APOE*23 with AD risk, there was a comparatively lower risk in these racial and ethnic groups for APOE*24 compared with APOE*34 (Figure 1A, Table, and eFigure 3 and eTable 6 in Supplement 1), suggesting a protective association of APOE*2 with risk of AD when seen together with APOE*4. This evidence concerns the gene APOE and Alzheimer disease.