APOE and Alzheimer disease: Lastly, the sex-by-age–specific association of APOE*34 with AD risk among White individuals (higher risk among women) was reproduced but shifted to ages 60 to 70 years (compared with ages 65-75 years in the previous largest analysis [N = 19 764], to our knowledge).7 The earlier shift in age may be explained by our harmonization of phenotype data (including age at onset).