Given the relative paucity of APOE*2 carriers in prior studies of Black and Hispanic individuals, a robust assessment of the association of APOE*2 with AD risk among these groups remained hampered.1,3 We observed that APOE*2, in addition to APOE*4, showed a stepwise pattern of attenuated ORs following White, Black, and Hispanic individuals; there was no association of APOE*2 with AD risk among East Asian and Hispanic individuals. This evidence concerns the gene APOE and Alzheimer disease.