In a meta-analysis of Black and Hispanic individuals, the APOE*44-by-sex effect estimate was concordant in direction (lower risk among women) but did not replicate and did not reveal an association with AD risk (OR, 0.86; 95% CI, 0.55-1.35; P = .52), while the APOE*34-by-sex association at ages 60 to 70 years was concordant in direction (greater risk among women) and replicated (OR, 1.72; 95% CI, 1.01-2.94; P = .046). Here, APOE is linked to Alzheimer disease.