This observation of attenuated effect estimates for APOE and AD risk among Hispanic individuals were observed in a prior, smaller study (using overlapping samples) conducted by Blue et al in 2019.25 Although global ancestry did not show a consistent effect on modulating the ORs for APOE with AD risk in Hispanic individuals, there were suggestive effects whereby Amerindian and European ancestry modulated the ORs for APOE*44 with AD risk (eTable 14 in Supplement 1). The gene discussed is APOE; the disease is Alzheimer disease.