APOE and Alzheimer disease: APOE-by-sex associations reached significance among White individuals for APOE*44, showing lower AD risk among women compared with men in non–age-stratified analyses (Table), and for APOE*34 at ages 60 to 70 years, showing an association with greater AD risk among women compared with men (Figure 2 and eFigure 4 in Supplement 1).