In a cancer context, gene bodies have been shown to lose DNA methylation and become hypomethylated compared with methylation in normal tissue, resulting in decreased transcription of these genes in the tumor tissue.49,50 This association would suggest that LRIG1 expression is decreased in the high neighborhood deprivation patient group, a conclusion further supported by our RNA sequencing gene expression results. The gene discussed is LRIG1; the disease is neoplasm.