LRIG1 and neoplasm: Notably, 2 CpG sites located in the gene body region of tumor suppressor genes, namely LRIG1 (leucine-rich repeats and immunoglobulin-like domains 1, cg26131019) and WWOX (WW domain–containing oxidoreductase, cg02171206), were among the associated loci in the unstratified analysis (Table 1; Figure 1).