Using a genome-wide discovery approach, our analysis revealed 8 CpG sites in which hypomethylation in tumors was positively correlated with increasing neighborhood deprivation, including CpG sites in 2 tumor suppressor genes, LRIG1 and WWOX. In the race-stratified analysis, NDI was associated with both the methylation status and expression of LRIG1 and WWOX among Black patients but not among White patients. Here, WWOX is linked to neoplasm.