Using a genome-wide discovery approach, our analysis revealed 8 CpG sites in which hypomethylation in tumors was positively correlated with increasing neighborhood deprivation, including CpG sites in 2 tumor suppressor genes, LRIG1 and WWOX. In the race-stratified analysis, NDI was associated with both the methylation status and expression of LRIG1 and WWOX among Black patients but not among White patients. This evidence concerns the gene LRIG1 and neoplasm.