Similarly, CTSK can promote CRC progression by promoting M2 polarization of TAM through a TLR4-mTOR-dependent pathway, while M2 macrophages can secrete chemokines such as IL7 and EGFR to activate the NFκB pathway to further promote tumor tissue invasion and metastasis [28, 35]. This evidence concerns the gene NFKB1 and colorectal carcinoma.