We also detected SLC7A11 upregulation in the myocardium of one BTHS patient (Fig. 8E) as well as in TAZ10 iPSC-CM and TazKO MEFs, which could be reverted by ISR inhibition with ISRIB in iPSC-CM and with siRNA-mediated knockdown of Atf4 in TazKO MEFs (Fig. 8F, Supplementary Fig. 9C, D). Here, ATF4 is linked to Barth syndrome.