INS and obesity due to melanocortin 4 receptor deficiency: As expected, obesity groups had significantly higher median values of SBP (p = 0.034), BMI Z-score, WC, TB-fat%, TB-FM, trunk-FM, trunk/appendicular FM ratio, FBG, fasting insulin, HOMA-IR, TC, TGs, LDL-C, non-HDL-C, and apelin-12 (p < 0.001) compared to the normal-weight-control group, while HDL-C was significantly lower in obese-DS compared to normal-weight-control group (p < 0.001).