Supernumerary copy of the critical region (HSA21) on the long arm of human chromosome 21 has been linked to one-third of the characteristics of DS [25], as well as strongly related to dysregulation of insulin and insulin signaling pathways [23], and has a key role in altered energy metabolism including increased oxidative stress, declined glucose and lipid metabolism, reduced energy production, and mitochondrial dysfunctions [26]. Here, INS is linked to Dravet syndrome.