Regarding obesity groups, obese-DS group had significantly higher median values of WC (p = 0.027), TB-fat% (p = 0.036), TB-FM (p = 0.001), trunk-FM (p < 0.001), trunk/appendicular FM ratio (p < 0.001), fasting insulin (p = 0.040), HOMA-IR (p = 0.038), TC (p < 0.001), TGs (p = 0.029), LDL-C (p < 0.001), non-HDL-C (p < 0.001), and apelin-12 (p < 0.001), and significantly lower HDL-C (p = 0.001) compared to obese-control (Table 1). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.