LEPR and Obesity: Like the GLP-1R, the MC4R is also a Gαs-coupled receptor, and setmelanotide is approved for weight loss in individuals with monogenic obesity caused by mutations in pro-opiomelanocortin, proprotein convertase subtilisin/kexin type 1, or leptin receptor deficiency and in individuals with Bardet-Biedl syndrome (Markham, 2021).