Our targeted sequencing panel, which includes the13 genes mentioned above (APC, ATM, BRCA1, BRCA2, CDH1, CHEK2, MLH1, MSH2, MSH6, PALB2, PTEN, STK11, and TP53), may be capable of evaluating germline predisposition for lung cancer, colorectal cancer, and breast cancer simultaneously (Figure S1). Here, MSH2 is linked to breast carcinoma.