AVP and Hypoglycemia: For example, Taheri et al.(2022) showed that male and female mice submitted to the insulintolerance test, simulating hypoglycemia as a stress factor, AVPR2 transcriptsincreased in the hypothalamus and decreased in the pituitary but just in males.These findings highlight the association between the AVP-AVPR2 complex and theactivation of the HPA system, which stimulates cortisol release.