HFE and hemochromatosis type 1: Hemochromatosis in whites of western European descent is associated with homozygosity for p.C282Y (rs1800562), a common missense allele of the HFE gene (homeostatic iron regulator, chromosome 6p22.2; OMIM accession *613609; NM_000410.4(HFE):c.845G>A (p.Cys282Tyr)) in linkage disequilibrium with human leukocyte antigen (HLA) A*03 (Barton et al., 2015; Feder et al., 1996).