These differences are largely due to socioeconomic factors, sugar consumption, and, in part, due to the population prevalence of genetic polymorphisms underlying the susceptibility for developing NAFLD.12,13 In the United States, the highest prevalence of NAFLD is seen in those of Hispanic heritage, possibly driven by the inheritance of the most prevalent polymorphism associated with NAFLD, patatin-like phospholipase domain–containing protein three (PNPLA3).14 This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.