HNF4A and hepatocellular carcinoma: One possible explanation for why it contributes to cell proliferation in our models is that HNF4α and YAP activities are intertwined.49–51 One mechanism proposed is that HNF4α competes with YAP in heterodimerization with TEAD4, inhibiting YAP activity.51 This indicates that a lack of HNF4α, triggered due to lack of O-GlcNAcylation, would cause an induction of YAP activity, leading to HCC progression.