An EGFR mutation is the most frequent driver of genetic variant in Asian patients with ADCs, while tumours with the EGFR wild-type sequence probably harboured other driver gene alterations such as KRAS, ALK, ROS1, RET, or BRAF, and their biological behaviour is considered similar to that of EGFR-mutated ADCs [20, 21]. Here, RET is linked to neoplasm.