TP53 and hepatocellular carcinoma: Our results revealed that HBDSP encoded by the 2.2-kb doubly spliced HBV variants exhibited pro-apoptotic effects in the wt-p53 HepG2 and SMMC-7721 cell lines but did not exhibit any effects in another two mut-p53 HCC cell lines (Huh7 and MHCC-97H cells).