IRS2 and neoplasm: In the homogeneous population, the most common mutations detected in tumor tissue were TP53, followed by PIK3CA, KMT2C, and PTEN; however, the top-ranking CNVs were found in different genes to those identified in a previous report: E2F3, IRS2, CCNE1, EGFR, NFIB, CCND1, and MYB (Jiang et al., 2019).