Among these pathways, the presence of PI3K/AKT signaling, HOTAIR regulatory pathway, Gαq signaling, ERK/MAPK signaling, regulation of eIF4 and p70S6K signaling, CDK5 signaling, small cell lung cancer signaling and PTEN signaling implied that an HFD promoted lung cancer development by regulating cell cycle and proliferation signaling pathways. This evidence concerns the gene CDK5 and small cell lung carcinoma.