STAT3 and cancer: Several critical gene set hallmarks and their corresponding gene expressions, including IFN-α response, IFN-γ response, complement and IL-6/JAK/STAT3 signaling, were positively enriched in the LC-HFD mice, suggesting that HFD helps cancer cells create a microenvironment related to immune and cytokine signaling and thus promotes cancer cell growth (Fig. 3B).