Another study showed reduced SOST expression and increased Wnt/β‐catenin signaling in the rat UMR106.01 osteosarcoma and mouse MLO‐A5 osteoblastic cell lines, consistent with a pro‐anabolic effect of hypoxia, although effects on in vitro mineralization were not reported (Genetos et al., 2010). This evidence concerns the gene SOST and osteosarcoma.