MGAM and diabetic kidney disease: In another American study, it was found that urinary B2-MG excretion was significantly correlated with the severity of tubulointerstitial damage in patients with DKD confirmed by renal biopsy, indicating that B2-MG also has a good predictive ability in the early stage of DKD (Mise et al., 2016a; Siddiqui et al., 2019).