Additionally, ultrasound-driven nano-motors have enabled intracellular small interfering RNA (siRNA) delivery and gene silencing, for example, using an assembly of polymeric micelles and liposomes suppress the anti-apoptosis gene sirtuin 2 (SIRT2) in nude mouse glioma model (Yin et al., 2013) and the GFP (HEK293-GFP) gene-mRNA expression in living human embryonic kidney 293 cells using gold nanowires (AuNW) wrapped with a Rolling Circle Amplification (RCA) DNA strand (Esteban-Fernández de Ávila et al., 2016). Here, SIRT2 is linked to central nervous system cancer.