Currently, advancements in genomic technologies have unveiled an expanding genetic landscape of OI, with the identification of at least 16 other genes associated with OI than COL1A1 and COL1A2, including genes involved in collagen synthesis, posttranslational modification, processing, crosslinking, osteoblast differentiation, and bone mineralization (3, 11–13). Here, COL1A1 is linked to osteogenesis imperfecta.