In 2012, Tremellen (13) introduced the DOGMA theory, positing that inadequate dietary habits can disrupt the equilibrium of gut microbiota, contributing to heightened intestinal mucosal permeability, which in turn allows for the infiltration of lipopolysaccharide (LPS) from Gram-negative colon bacteria by entering the bloodstream, thus triggering the immune response, and impeding insulin receptor function, ultimately resulting in increased levels of insulin and androgens in individuals with PCOS. The gene discussed is INS; the disease is polycystic ovary syndrome.