INS and polycystic ovary syndrome: Insulin induces androgen production in the adipose tissue in PCOS via upregulation of aldo-keto reductase type 1C3 (AKR1C3) activity, which can convert classical androgen and 11-oxygenated androgens into potent androgen forms, namely, T or DHT and 11-ketotestosterone(11K-T), respectively (26).