Another study has investigated the expression profiles of Wnt/β-catenin signaling genes in human oocytes, finding that the expression of WNT1 and GSK3β genes was elevated in PCOS patients, while there was no significant difference between the PCOS group and the control group in terms of APC and β-catenin expression levels. This evidence concerns the gene WNT1 and polycystic ovary syndrome.