NFKB1 and polycystic ovary syndrome: The S100‐A9 protein in exosomes from the follicle fluids of PCOS patients may activate the NF‐κB signaling pathway (116), while human umbilical cord mesenchymal-stem-cell-derived exosomes (hUC-MSC-exos) can inhibit NF-κB signaling via stimulation of the phosphorylation and degradation of Ik-B, increasing the expression of anti-inflammatory cytokines IL-10, and are capable of activating M2 macrophage polarization.