HMGCR and Insulin resistance: The suggested mechanisms for the beneficial impacts of L-carnitine on lipid profile include reducing the conversion of free fatty acids (FFAs) to triglycerides (14); decreasing insulin resistance (69); stimulating apolipoprotein-A1 production, which is the major apolipoprotein of HDL-C (14); and blunting cholesterol synthesis via prohibiting the hydroxymethylglutaryl CoA reductase (HMG-CoA) activity (70), being implicated in weight reduction and consequently lipid profile improvement (68).