Mild, asymptomatic hypercalcemia- Discontinue Vitamin D- Low-calcium formula- If persistent hypercalcemia, consider glucocorticoidsSevere hypercalcemia (>12 mg/dl) or overt symptoms- Hospital admission- Discontinue Vitamin D- Low-calcium formula or parenteral nutrition- iv hydration with saline and then furosemide infusion- Consider subcutaneous Calcitonin- If persistent hypercalcemia, consider iv Pamidronate, one or more doses. The gene discussed is CALCA; the disease is Hypercalcemia.