Interestingly, significant upregulation of KRT17 has been found in diabetic foot ulcer tissues; however, keratin subtypes associated with wound activation (KRT6 and KRT16) and with cell differentiation (KRT1, KRT2, and KRT10) were downregulated (52), suggesting that KRT17 upregulation may be involved in delayed healing of diabetic foot ulcers. The gene discussed is KRT1; the disease is diabetic foot.