Altered expression of specific imprinted genes is also known to exert notable effects on metabolic health: thus, higher expression of the maternally expressed imprinted genes CDKN1C and H19, and lower expression of the paternally expressed imprinted gene DLK1, each protects against diet-induced obesity in mice [19, 37, 56]. The gene discussed is CDKN1C; the disease is Obesity.