Furthermore, in murine models of heart failure with TET2 deficiency in hematopoietic cells, cardiac function worsened due to the elevation of IL-1β/NLRP3 inflammasome, and the models responded better to IL-1β/NLRP3 inflammasome inhibition (Sano et al., 2018b). The gene discussed is NLRP3; the disease is heart failure.