Similarly, in dietary models of non-alcoholic steatohepatitis, mice transplanted with TET2-deficient hematopoietic cells demonstrated more severe liver inflammation and fibrosis due to elevated NLRP3 inflammasome and downstream inflammatory cytokine expression in TET2-deficient macrophages (Wong et al., 2023). The gene discussed is TET2; the disease is metabolic dysfunction-associated steatohepatitis.