Finally, the studies described above suggested that hypertension-related disorders such as PE, GDM, CVDs, and T2DM alter specific CXC chemokines, including CXCL5, CXC10/CXCR3, CXCL12/CXCR4, CXCL16/CXCR6, and CX3CL1/CX3CR1. This evidence concerns the gene CX3CL1 and type 2 diabetes mellitus.