51. Du et al. showed significant interactions between LMAN1 and MCFD2, and F8 and TMED10 by PPI analysis in their study of the expression and clinical characteristics of LMAN1 in gliomas and its effects on cell growth and invasion lead to the hypothesis that TMED10 may interact with LMAN1 to affect glioma cell growth and invasion52. This evidence concerns the gene LMAN1 and central nervous system cancer.