Patients with SS xerostomia have considerably lower levels of TMED10, PDIA4, and CanX gene expression compared to healthy controls, but not statistically different from SS non-xerostomia patients, demonstrating that TMED10 gene expression is reduced in xerostomia patients by a different mechanism than in Alzheimer's disease patients and that SS-associated xerostomia is not caused by increased autophagy activation104. This evidence concerns the gene CANX and xerostomia.