Considering that cav 1 prevents hydrogen peroxide-induced oxidative damage to lung carcinoma cells 107, and higher cav 1 expression enhances the sensitivity of A549 cells to the anti-cancer drug doxorubicin 106, it is evident that downregulating CAV1 could be unfavorable for NSCLC. The gene discussed is CAV1; the disease is non-small cell lung carcinoma.