NLRP3 and Sepsis: During the progression of sepsis, the assembly of the TXNIP-NLRP3 complex in monocytes can be embedded into CD63+ exosomes, transported from circulating monocytes to local macrophages, and promote the cleavage of inactive IL-1β and IL-18 in macrophages, exacerbating cardiovascular inflammation and myocardial dysfunction 66.