AGTR1 and spontaneous coronary artery dissection: Notably, a recent case-control study by Civieri et al. reported a significantly higher prevalence of autoantibodies targeting angiotensin-II receptor type 1 and endothelin-1 receptor type A in SCAD patients compared to controls (including healthy individuals and those with atherosclerotic CAD), emphasizing the potential role of autoimmunity in SCAD pathophysiology (64).