CBLL1, also known as E3 ubiquitin-protein ligase Hakai, possesses a RING-finger domain involved in the ubiquitination, endocytosis, and degradation of herin and plays a significant role in TNF or cytokine reactions in periodontitis (21), is a significant regulator in TNF or cytokine reactions in periodontitis (22). Here, CBLL1 is linked to periodontitis.